Ec number : 2.5.1.6
 
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Entry Information
Entry status  (1)
REL
(111)
 
Experimental methods  (2)
X-ray diffraction
(107)
Electron Microscopy
(4)
 
Authors  (402)
Antonyuk SV
(15)
Hasnain SS
(15)
Schimpl M
(14)
Argyrou A
(13)
Bagal SK
(13)
Cheung T
(13)
Chiarparin E
(13)
De Fusco C
(13)
Evans L
(13)
Grondine M
(13)
Lynch JT
(13)
Mato JM
(13)
Scott JS
(13)
Tentarelli S
(13)
Vazquez-Chantada M
(13)
Biller SA
(9)
Chen Y
(9)
Gross S
(9)
Hyer ML
(9)
Jin L
(9)
Konteatis Z
(9)
Mandley E
(9)
Marjon K
(9)
Markham GD
(9)
Marks KM
(9)
Murtie J
(9)
Padyana AK
(9)
Panmanee J
(9)
Sui Z
(9)
Takusagawa F
(9)
Travins J
(9)
Bagal S
(7)
Borjesson U
(7)
Bradley-Clarke J
(7)
Börjesson U
(7)
Collie I
(7)
Dauter Z
(7)
Narasimhan P
(7)
O'Neill PM
(7)
Robb G
(7)
Ruszkowski M
(7)
Sanders MG
(7)
Sekula B
(7)
Smith JM
(7)
Stubbs C
(7)
Underwood E
(7)
Wagner DJ
(7)
Askin S
(6)
Atkinson SJ
(6)
Coen M
(6)
Collie IT
(6)
Cornelissen NV
(6)
Dale IL
(6)
Dillman K
(6)
Dranow DM
(6)
Edwards TE
(6)
Feron LJ
(6)
Foster AJ
(6)
Gao Y
(6)
Huber TD
(6)
Kamitori S
(6)
Kantae V
(6)
Klocker N
(6)
Klöcker N
(6)
Kuemmel D
(6)
Kummel D
(6)
Kümmel D
(6)
Lamont GM
(6)
Lamont S
(6)
Lu SC
(6)
Marina A
(6)
Murray B
(6)
Nilsson Lill S
(6)
Peters A
(6)
Phillips Jr GN
(6)
Rentmeister A
(6)
Robb GR
(6)
Rojas AL
(6)
Saeh J
(6)
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
(6)
Smith J
(6)
Srinivasan B
(6)
Sun Y
(6)
Thorson JS
(6)
Tong S
(6)
Wagner D
(6)
Walsh JJ
(6)
Watson D
(6)
Williamson B
(6)
Barnett A
(5)
Dang L
(5)
DeLaBarre B
(5)
Fang C
(5)
Gonzalez B
(5)
González B
(5)
Hermoso JA
(5)
Jiang F
(5)
Kalev P
(5)
Liu Z
(5)
Nagaraja R
(5)
 
More...
 
Homo / hetero assembly  (2)
homo
(105)
hetero
(6)
 
Assembly composition  (2)
protein structure
(105)
protein/protein complex
(6)
 
Assembly polymer count  (7)
dimer
(72)
tetramer
(32)
hexamer
(3)
dodecamer
(1)
monomer
(1)
octamer
(1)
pentadecamer
(1)
 
Resolution distribution
0.5 - 1
(1)
1.0 - 1.5
(37)
1.5 - 2
(25)
2.0 - 2.5
(22)
2.5 - 3
(17)
3.0 - 3.5
(8)
3.5 - 4
(1)
 
Release year distribution
1995 - 2000
(8)
2000 - 2005
(7)
2005 - 2010
(3)
2010 - 2015
(13)
2015 - 2020
(30)
2020 - 2025
(65)
 
Journal  (33)
J Med Chem
(24)
FEBS J
(10)
To be published
(10)
Int J Biol Macromol
(7)
Biochemistry
(6)
J Mol Biol
(5)
Bioorg Med Chem Lett
(4)
Chembiochem
(4)
IUCrJ
(3)
J Agric Food Chem
(3)
J Am Chem Soc
(3)
J Biol Chem
(3)
Proc Natl Acad Sci U S A
(3)
Tuberculosis (Edinb)
(3)
Acta Crystallogr D Struct Biol
(2)
Angew Chem Int Ed Engl
(2)
J Struct Biol
(2)
Protein Sci
(2)
ACS Chem Biol
(1)
Acta Crystallogr F Struct Biol Commun
(1)
BMC Struct Biol
(1)
Bioorg Med Chem
(1)
Cell Rep
(1)
Chem Sci
(1)
EBioMedicine
(1)
FEBS J.
(1)
J Biomol Struct Dyn
(1)
JACS Au
(1)
Nat Chem Biol
(1)
Nature
(1)
PLoS One
(1)
Science
(1)
mBio
(1)
 
Macromolecules
Organism name  (21)
Homo sapiens
(59)
Escherichia coli
(12)
Arabidopsis thaliana
(6)
Rattus norvegicus
(5)
Saccharolobus solfataricus P2
(5)
Methanocaldococcus jannaschii DSM 2661
(4)
Corynebacterium glutamicum ATCC 13032
(3)
Cryptosporidium hominis
(2)
Neisseria gonorrhoeae FA 1090
(2)
Pyrococcus furiosus DSM 3638
(2)
Burkholderia pseudomallei
(1)
Cryptosporidium parvum Iowa II
(1)
Entamoeba histolytica
(1)
Escherichia coli K-12
(1)
Lactiplantibacillus plantarum
(1)
Medicago truncatula
(1)
Mycobacterium avium 104
(1)
Mycobacterium marinum M
(1)
Mycobacterium tuberculosis
(1)
Thermococcus kodakarensis
(1)
Thermus thermophilus HB27
(1)
 
Molecule name  (22)
AdoMet synthase 2
(59)
MAT 2
(59)
Methionine adenosyltransferase 2
(59)
MAT-II
(55)
Methionine adenosyltransferase II
(55)
S-adenosylmethionine synthase isoform type-2
(55)
S-adenosylmethionine synthase
(41)
AdoMet synthase
(36)
Methionine adenosyltransferase
(36)
MAT
(24)
AdoMet synthase 1
(11)
MAT 1
(11)
Methionine adenosyltransferase 1
(11)
MAT-I/III
(9)
Methionine adenosyltransferase I/III
(9)
S-adenosylmethionine synthase isoform type-1
(9)
S-adenosylmethionine synthase 2
(4)
S-adenosylmethionine synthase 1
(2)
Uncharacterized protein
(2)
S-adenosylmethionine synthase-like protein
(1)
S-adenosylmethionine synthetase (SAM)
(1)
S-adenosylmethionine synthetase, putative
(1)
 
Molecule type  (1)
Protein
(111)
 
Representative Structures
Representative Structures
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Entries 1 to 10 of 111
Entries 1 to 10 of 111
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Crystal Structure of S-Adenosylmethionine synthetase (MetK/Mat) from Cryptosporidium parvum
Ohren JF, Viola RE
Acta Crystallogr F Struct Biol Commun (2019) [PMID: 30950830  ]
Assembly composition: protein only structure
Bound ligands: K    MG    K    CL    MG   
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-176945 (Preferred)   search this ID
PDBe-KB: Q5CYE4   
X-ray diffraction
1.85Å resolution
Released: 16 Jan 2019
Model geometry
Fit model/data
6c07
6c07
6c07
Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAM and PPi
Wang F, Hurley KA, Helmich KE, Singh S, Bingman CA, Thorson JS, Phillips Jr GN, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
FEBS J (2014) [PMID: 24649856  ]
Assembly composition: protein only structure
Bound ligands: MG    DPO    SAM    SAM    DPO    MG    PO4   
Modified residues: MSE    MSE   
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189100 (Preferred)   search this ID
PDBe-KB: Q980S9   
X-ray diffraction
2.39Å resolution
Released: 1 May 2013
Model geometry
Fit model/data
4k0b
4k0b
4k0b
Structural insights of MAT enzymes: MATa2b complexed with SAM and PPNP
Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL
IUCrJ (2014) [PMID: 25075345  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    SAM    SAM    PPK    MG    EDO    PPK   
Assembly name: Methionine adenosyltransferase 2 subunit beta and S-adenosylmethionine synthase isoform type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151918 (Preferred)   search this ID
PDBe-KB: P31153    Q9NZL9   
X-ray diffraction
2.34Å resolution
Released: 16 Jul 2014
Model geometry
Fit model/data
4ndn
4ndn
4ndn
Methionine Adenosyltransferase
Schlesier J, Siegrist J, Gerhardt S, Andexer JN, Einsle O
BMC Struct Biol (2013) [PMID: 24134203  ]
Assembly composition: protein only structure
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-177276 (Preferred)   search this ID
PDBe-KB: Q5JF22   
X-ray diffraction
2Å resolution
Released: 19 Mar 2014
Model geometry
Fit model/data
4l4q
4l4q
4l4q
Crystal structure of S-Adenosylmethionine synthase from Sulfolobus solfataricus complexed with SAM and PPi
Wang F, Hurley KA, Helmich KE, Singh S, Bingman CA, Thorson JS, Phillips Jr GN, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
FEBS J (2014) [PMID: 24649856  ]
Assembly composition: protein only structure
Bound ligands: MG    DPO    SAM    SAM    DPO    MG    PO4   
Modified residues: MSE    MSE   
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189100 (Preferred)   search this ID
PDBe-KB: Q980S9   
X-ray diffraction
2.189Å resolution
Released: 3 Jul 2013
Model geometry
Fit model/data
4l7i
4l7i
4l7i
Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAE and PPi
Wang F, Hurley KA, Helmich KE, Singh S, Bingman CA, Thorson JS, Phillips Jr GN, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
FEBS J (2014) [PMID: 24649856  ]
Assembly composition: protein only structure
Bound ligands: MG    DPO    S7M    DPO    S7M    MG    PO4   
Modified residues: MSE    MSE   
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189100 (Preferred)   search this ID
PDBe-KB: Q980S9   
X-ray diffraction
2.494Å resolution
Released: 19 Jun 2013
Model geometry
Fit model/data
4l2z
4l2z
4l2z
Structural insights of MAT enzymes: MATa2b complexed with SAM
Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL
IUCrJ (2014) [PMID: 25075345  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    SAM    SAM    MG    EDO    PO4   
Assembly name: Methionine adenosyltransferase 2 subunit beta and S-adenosylmethionine synthase isoform type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151918 (Preferred)   search this ID
PDBe-KB: P31153    Q9NZL9   
X-ray diffraction
2.59Å resolution
Released: 16 Jul 2014
Model geometry
Fit model/data
4ktt
4ktt
4ktt
Structural insights of MAT enzymes: MATa2b complexed with adenosine and pyrophosphate
Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL
IUCrJ (2014) [PMID: 25075345  ]
Source organism: Homo sapiens  
Assembly composition: protein/protein complex
Bound ligands: MG    ADN    ADN    POP    MG    POP    EDO    PO4   
Assembly name: Methionine adenosyltransferase 2 subunit beta and S-adenosylmethionine synthase isoform type-2 (Preferred)   search this complex
PDBe complex ID: PDB-CPX-151918 (Preferred)   search this ID
PDBe-KB: P31153    Q9NZL9   
X-ray diffraction
3.3Å resolution
Released: 16 Jul 2014
Model geometry
Fit model/data
4ktv
4ktv
4ktv
Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus
Wang F, Hurley KA, Helmich KE, Singh S, Bingman CA, Thorson JS, Phillips Jr GN, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
FEBS J (2014) [PMID: 24649856  ]
Assembly composition: protein only structure
Modified residues: MSE    MSE   
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-189100 (Preferred)   search this ID
PDBe-KB: Q980S9   
X-ray diffraction
2.214Å resolution
Released: 14 Nov 2012
Model geometry
Fit model/data
4hpv
4hpv
4hpv
Crystal structure of S-adenosylmethionine synthetase Rv1392 from Mycobacterium tuberculosis
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Tuberculosis (Edinb) (2015) [PMID: 25613812  ]
Assembly composition: protein only structure
Bound ligands: NA    NA   
Assembly name: S-adenosylmethionine synthase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-161520 (Preferred)   search this ID
PDBe-KB: P9WGV1   
X-ray diffraction
1.85Å resolution
Released: 17 Aug 2011
Model geometry
Fit model/data
3tde
3tde
3tde
...
Entries 1 to 10 of 111
Entries 1 to 10 of 111