Ec number : 2.6.1.5
 
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Entry Information
Entry status  (1)
REL
(4)
 
Experimental methods  (1)
X-ray diffraction
(4)
 
Authors  (57)
Abendroth J
(1)
Abramov A
(1)
Alcolea PJ
(1)
Alonso A
(1)
Andersson J
(1)
Arrowsmith CH
(1)
Berglund H
(1)
Bevan DR
(1)
Blankenfeldt W
(1)
Collins R
(1)
Dahlgren LG
(1)
Edwards AM
(1)
Edwards T
(1)
Flodin S
(1)
Flores A
(1)
Graslund S
(1)
Hammarstrom M
(1)
Han Q
(1)
Hecht HJ
(1)
Hunter GR
(1)
Johansson A
(1)
Johansson I
(1)
Kalisz HM
(1)
Karlberg T
(1)
Kotenyova T
(1)
Larraga V
(1)
Lehtio L
(1)
Lemkul JA
(1)
Li J
(1)
Lorimer D
(1)
Mehere P
(1)
Mehere PV
(1)
Moche M
(1)
Montemartini M
(1)
Montemartini-Kalisz M
(1)
Moreno MA
(1)
Myler PJ
(1)
Nilsson ME
(1)
Nordlund P
(1)
Nowicki C
(1)
Nyman T
(1)
Olesen K
(1)
Persson C
(1)
Robinson H
(1)
Sagemark J
(1)
Schuler H
(1)
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
(1)
Structural Genomics Consortium (SGC)
(1)
Thorsell AG
(1)
Tresaugues L
(1)
Van Den Berg S
(1)
Vavricka CJ
(1)
Weigelt J
(1)
Welin M
(1)
Wikstrom M
(1)
Wisniewska M
(1)
Zhang S
(1)
 
Homo / hetero assembly  (1)
homo
(4)
 
Assembly composition  (1)
protein structure
(4)
 
Assembly polymer count  (1)
dimer
(4)
 
Resolution distribution
2.0 - 2.5
(3)
2.5 - 3
(1)
 
Release year distribution
1995 - 2000
(1)
2005 - 2010
(2)
2010 - 2015
(2)
 
Journal  (4)
Acta Crystallogr F Struct Biol Commun
(1)
Protein Cell
(1)
Protein Sci
(1)
To be published
(1)
 
Macromolecules
Organism superkingdom  (1)
Eukaryota
(4)
 
Organism name  (4)
Homo sapiens
(1)
Leishmania infantum
(1)
Mus musculus
(1)
Trypanosoma cruzi
(1)
 
Molecule name  (4)
Tyrosine aminotransferase
(4)
L-tyrosine:2-oxoglutarate aminotransferase
(3)
TAT
(3)
Aminotransferase class I/classII large domain-containing protein
(1)
 
Molecule type  (1)
Protein
(4)
 
Gene names  (3)
TAT
(2)
LINJ_36_2490
(1)
Tat
(1)
 
Interacting ligands  (2)
CL : CHLORIDE ION
(1)
PLP : PYRIDOXAL-5'-PHOSPHATE
(1)
 
Function and Biology
EC number / name  (1)
2.6.1.5 : Tyrosine transaminase
(4)
 
Biological function  (5)
L-tyrosine-2-oxoglutarate transaminase activity
(4)
pyridoxal phosphate binding
(4)
transaminase activity
(4)
catalytic activity
(3)
transferase activity
(2)
 
Biological process  (5)
amino acid metabolic process
(4)
biosynthetic process
(4)
aromatic amino acid metabolic process
(3)
tyrosine catabolic process
(2)
L-phenylalanine catabolic process
(1)
 
Biological cell component  (2)
cytoplasm
(1)
mitochondrion
(1)
 
Compound cofactor class  (1)
Pyridoxal 5'-phosphate
(1)
 
Sequence and Structure classification
SCOP fold  (1)
PLP-dependent transferase-like
(1)
 
SCOP family  (1)
AAT-like
(1)
 
CATH class  (1)
Alpha Beta
(4)
 
CATH topology  (2)
Aspartate Aminotransferase, domain 1
(4)
Aspartate Aminotransferase; domain 2
(4)
 
Pfam accession / name  (1)
PF00155 : Aminotran_1_2
(4)
 
Representative Structures
Representative Structures
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Entries 1 to 4 of 4
Entries 1 to 4 of 4
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CRYSTAL STRUCTURE OF TYROSINE AMINOTRANSFERASE FROM TRYPANOSOMA CRUZI
Blankenfeldt W, Montemartini M, Hunter GR, Kalisz HM, Nowicki C, Hecht HJ
Protein Sci (1999) [PMID: 10595543  ]
Source organism: Trypanosoma cruzi  
Assembly composition: protein only structure
Modified residues: LLP    LLP   
Assembly name: Tyrosine aminotransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-152616 (Preferred)   search this ID
PDBe-KB: P33447   
X-ray diffraction
2.5Å resolution
Released: 27 Sep 1999
Model geometry
Fit model/data
1bw0
1bw0
1bw0
Crystal structural of mouse tyrosine aminotransferase
Mehere PV, Han Q, Lemkul JA, Robinson H, Bevan DR, Li J
Protein Cell (2010) [PMID: 21153519  ]
Source organism: Mus musculus  
Assembly composition: protein only structure
Modified residues: LLP    LLP   
Assembly name: Tyrosine aminotransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-185865 (Preferred)   search this ID
PDBe-KB: Q8QZR1   
X-ray diffraction
2.91Å resolution
Released: 3 Nov 2010
Model geometry
Fit model/data
3pdx
3pdx
3pdx
Crystal structure of Tyrosine aminotransferase from Leishmania infantum
Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Acta Crystallogr F Struct Biol Commun (2014) [PMID: 24817714  ]
Source organism: Leishmania infantum  
Assembly composition: protein only structure
Bound ligands: CL   
Modified residues: LLP    LLP   
Assembly name: Aminotransferase class I/classII large domain-containing protein (Preferred)   search this complex
PDBe complex ID: PDB-CPX-107327 (Preferred)   search this ID
PDBe-KB: A4IDL0   
X-ray diffraction
2.35Å resolution
Released: 26 Mar 2014
Model geometry
Fit model/data
4ix8
4ix8
4ix8
Human Tyrosine Aminotransferase
Karlberg T, Moche M, Andersson J, Arrowsmith CH, Berglund H, Collins R, Dahlgren LG, Edwards AM, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson A, Johansson I, Kotenyova T, Lehtio L, Nilsson ME, Nordlund P, Nyman T, Olesen K, Persson C, Sagemark J, Thorsell AG, Tresaugues L, Van Den Berg S, Weigelt J, Welin M, Wikstrom M, Wisniewska M, Schuler H, Structural Genomics Consortium (SGC)
To be published
Source organism: Homo sapiens  
Assembly composition: protein only structure
Bound ligands: PLP    PLP   
Assembly name: Tyrosine aminotransferase (Preferred)   search this complex
PDBe complex ID: PDB-CPX-148151 (Preferred)   search this ID
PDBe-KB: P17735   
X-ray diffraction
2.3Å resolution
Released: 19 Aug 2008
Model geometry
Fit model/data
3dyd
3dyd
3dyd
Entries 1 to 4 of 4
Entries 1 to 4 of 4