Entry status  (1)

REL

(228)

Experimental methods  (2)

X-ray diffraction

(179)

Electron Microscopy

(49)

Authors  (702)

Christianson DW

(60)

Jung M

(34)

Lancelot J

(31)

Romier C

(31)

Sippl W

(31)

Pierce RJ

(30)

Marek M

(29)

Schmidtkunz K

(28)

Decroos C

(26)

Melesina J

(25)

Shaik TB

(25)

Chakrabarti A

(24)

Robaa D

(24)

Heimburg T

(19)

Holl R

(18)

Suzuki T

(18)

Da Veiga C

(17)

Ennifar E

(17)

Kalinin D

(17)

Ramos-Morales E

(17)

Barnard RJO

(16)

Fierke CA

(16)

Klein DJ

(16)

Bowman CM

(15)

Wang C

(15)

Deardorff MA

(14)

Myers RW

(14)

Hai Y

(13)

Howell BJ

(13)

Liu J

(13)

Yu W

(13)

Dowling DP

(12)

Li H

(12)

Christianson KE

(11)

Clausen D

(11)

Gattis SG

(11)

Li W

(11)

Porter NJ

(11)

Wu G

(11)

Wu J

(11)

Zhang X

(11)

Zhang Y

(11)

Fells J

(10)

Kozlowski J

(10)

De Francesco R

(9)

Gallinari P

(9)

Steinkühler C

(9)

Wang P

(9)

Bowman CB

(8)

Buck IM

(8)

Carfi A

(8)

Carfí A

(8)

Cleasby A

(8)

Cons BD

(8)

Dawson L

(8)

Duffy JL

(8)

East C

(8)

Futamura T

(8)

Goto S

(8)

Griffiths-Jones C

(8)

Hashimoto T

(8)

He J

(8)

Heightman TD

(8)

Ishikawa S

(8)

Ito H

(8)

Jones P

(8)

Kaneko Y

(8)

Kawato T

(8)

Kondo K

(8)

Kurihara N

(8)

McCarthy JM

(8)

Miyamura S

(8)

Mori Y

(8)

Moser J-AS

(8)

Moser JA

(8)

Nagase T

(8)

Nakaishi Y

(8)

Reeks J

(8)

Sato A

(8)

Schopf P

(8)

Schwabe JWR

(8)

Schöpf P

(8)

Steinkuhler C

(8)

Tai K

(8)

Tamai T

(8)

Tamanini E

(8)

Tisi D

(8)

Wang M

(8)

Watson PR

(8)

Woolford AJ

(8)

Zheng X

(8)

Chao WCH

(7)

Christianson NH

(7)

Chu C

(7)

Dong S

(7)

Fairall L

(7)

Gantt SL

(7)

Gao X

(7)

Guan J

(7)

Gullett LE

(7)

 

More...

Homo / hetero assembly  (2)

homo

(141)

hetero

(87)

Assembly composition  (4)

protein structure

(141)

protein/protein complex

(61)

DNA/protein complex

(25)

D-protein/protein complex

(1)

Assembly polymer count  (17)

monomer

(128)

dimer

(32)

tetramer

(19)

hexadecamer

(11)

pentamer

(9)

heptamer

(6)

hexamer

(5)

trimer

(5)

decamer

(2)

heptadecamer

(2)

octadecamer

(2)

undecamer

(2)

24-mer

(1)

dodecamer

(1)

octamer

(1)

pentadecamer

(1)

tetradecamer

(1)

Resolution distribution

1.0 - 1.5

(11)

1.5 - 2

(81)

2.0 - 2.5

(53)

2.5 - 3

(40)

3.0 - 3.5

(25)

3.5 - 4

(10)

4.0 - 4.5

(4)

6.0 - 6.5

(1)

7.5 - 8

(1)

8.5 - 9

(1)

19.0 - 19.5

(1)

Release year distribution

2000 - 2005

(6)

2005 - 2010

(25)

2010 - 2015

(39)

2015 - 2020

(87)

2020 - 2025

(104)

2025 - 2030

(4)

Journal  (32)

Biochemistry

(26)

J Med Chem

(24)

Nat Commun

(18)

J Biol Chem

(17)

ACS Med Chem Lett

(15)

Nat Chem Biol

(15)

Bioorg Med Chem Lett

(12)

ACS Chem Biol

(9)

Cell Res

(9)

Sci Adv

(8)

To be published

(8)

J Mol Biol

(7)

Nature

(6)

Nucleic Acids Res

(6)

ChemMedChem

(5)

Nat Struct Mol Biol

(5)

PLoS Pathog

(5)

Structure

(5)

Bioorg Med Chem

(4)

J Struct Biol

(4)

Proc Natl Acad Sci U S A

(4)

Sci Signal

(3)

Cell Discov

(2)

EMBO Rep

(2)

Mol Cell

(2)

Curr Res Struct Biol

(1)

Elife

(1)

Eur J Med Chem

(1)

J Am Chem Soc

(1)

Molecules

(1)

Plant Physiol

(1)

Sci Rep

(1)

Organism name  (10)

Homo sapiens

(139)

Schistosoma mansoni

(36)

Saccharomyces cerevisiae

(19)

Danio rerio

(15)

Saccharomyces cerevisiae S288C

(12)

Arabidopsis thaliana

(2)

Schizosaccharomyces pombe

(2)

Schizosaccharomyces pombe 972h-

(2)

Escherichia coli

(1)

Mus musculus

(1)

Molecule name  (53)

Histone deacetylase 8

(88)

HD8

(53)

Protein deacetylase HDAC8

(53)

Protein decrotonylase HDAC8

(53)

HD2

(44)

Histone deacetylase 2

(44)

Protein deacylase HDAC2

(44)

histone deacetylase

(36)

Histone deacetylase RPD3

(25)

Transcriptional regulatory protein RPD3

(25)

HD4

(19)

Histone deacetylase 4

(19)

Protein deacetylase HDAC6

(16)

Tubulin-lysine deacetylase HDAC6

(16)

Histone deacetylase 6

(15)

HD1

(11)

Histone deacetylase 1

(11)

Protein deacetylase HDAC1

(11)

Protein deacylase HDAC1

(11)

HD7

(8)

Histone deacetylase 7

(7)

HD7a

(6)

Histone deacetylase 7A

(6)

Protein deacetylase HDAC7

(6)

Histone deacetylase HDA1

(5)

Cryptic loci regulator 6

(3)

HD7b

(3)

HD9

(3)

Histone deacetylase 7B

(3)

Histone deacetylase 9

(3)

Histone deacetylase clr6

(3)

Histone deacetylase-related protein

(3)

MEF2-interacting transcription repressor MITR

(3)

Antigen NY-CO-9

(2)

HD5

(2)

Histone deacetylase 5

(2)

Cryptic loci regulator 3

(1)

E3 ubiquitin-protein ligase HDAC6

(1)

HD3

(1)

Histone deacetylase 15

(1)

Histone deacetylase 3

(1)

Histone deacetylase HOS3

(1)

Histone deacetylase clr3

(1)

MBP

(1)

MMBP

(1)

Maltodextrin-binding protein

(1)

Maltose-binding protein

(1)

Maltose/maltodextrin-binding periplasmic protein

(1)

Protein deacetylase HDAC3

(1)

Protein deacylase HDAC3

(1)

Putative histone deacetylase 1, 2,3

(1)

RPD3-2

(1)

SMAP45

(1)

Molecule type  (1)

Protein

(228)

Gene names  (52)

HDAC8

(88)

CDA07

(53)

HDACL1

(53)

HDAC2

(44)

MOF6

(25)

N0305

(25)

REC3

(25)

RPD3

(25)

SDI2

(25)

SDS6

(25)

YNL330C

(25)

HDAC4

(19)

KIAA0288

(19)

hdac6

(15)

HDAC1

(11)

RPD3L1

(11)

HDAC7

(8)

HDAC7A

(6)

HDA1

(5)

N2819

(5)

YNL021W

(5)

SPBC36.05c

(3)

clr6

(3)

HDAC5

(2)

HDAC7B

(2)

HDAC9

(2)

HDRP

(2)

KIAA0600

(2)

KIAA0744

(2)

MITR

(2)

At3g18520

(1)

At5g35600

(1)

HDA15

(1)

HDA7

(1)

HDAC3

(1)

HDAC6

(1)

HOS3

(1)

Hdac7b

(1)

Hdac9

(1)

Hdrp

(1)

JM21

(1)

JW3994

(1)

K2K18.5

(1)

KIAA0901

(1)

LPH11W

(1)

MYF24_23

(1)

Mitr

(1)

SPBC800.03

(1)

YPL116W

(1)

b4034

(1)

clr3

(1)

malE

(1)

Interacting Molecules  (101)

Transcriptional regulatory protein SIN3

(25)

Chromatin modification-related protein EAF3

(23)

Transcriptional regulatory protein RCO1

(23)

Histone H4

(17)

Histone H2B 1.1

(14)

Histone H3.2

(14)

Histone H2A type 1

(13)

Kelch repeat and BTB domain-containing protein 4

(8)

187bp DNA

(5)

MADS-box domain-containing protein

(5)

Metastasis-associated protein MTA1

(5)

REST corepressor 1

(5)

HDA1 complex subunit 2

(4)

HDA1 complex subunit 3

(4)

Histone deacetylase HDA1

(4)

PHD finger protein 12

(4)

Paired amphipathic helix protein Sin3b

(4)

3-DNA

(3)

5-DNA

(3)

Fluor-de-Lys tetrapeptide assay substrate

(3)

Histone H2A type 1-B/E

(3)

Histone H2B type 1-K

(3)

Histone H3.1

(3)

Methyl-CpG-binding domain protein 2

(3)

Nuclear receptor corepressor 2

(3)

RbAp48-related WD40 repeat-containing protein prw1

(3)

Wisdom 601 DNA (167-MER)

(3)

tetrapeptide substrate

(3)

Chromatin modification-related protein eaf3

(2)

Cph1

(2)

DNA (352-MER)

(2)

Deoxynucleotidyltransferase terminal-interacting protein 1

(2)

HDAC8 Fluor de Lys tetrapeptide substrate

(2)

Histone H2A

(2)

MADS box dsDNA: AACTATTTATAAGA

(2)

Mitotic deacetylase-associated SANT domain protein

(2)

Mortality factor 4-like protein 1

(2)

Paired amphipathic helix protein pst2

(2)

Transcriptional regulatory protein DEP1

(2)

Transcriptional regulatory protein PHO23

(2)

Transcriptional regulatory protein RXT2

(2)

Transcriptional regulatory protein RXT3

(2)

Transcriptional regulatory protein SAP30

(2)

Transcriptional regulatory protein SDS3

(2)

U2M-ASN-PRO-GLU-GLN-DLY-TRP-GLY peptide macrocycle

(2)

(SHA)W(DTH)DN(DSN)(DME)(DAS)K peptide macrocycle

(1)

14-3-3 protein gamma

(1)

167bp DNA

(1)

ACE-ARG-HIS-ALY-ALY-MCM

(1)

Ankyrin repeat family A protein 2

(1)

Cellular tumor antigen p53

(1)

Chromatin modification-related protein png2

(1)

Cph2

(1)

DNA (145-MER)

(1)

DNA (164-MER)

(1)

DNA (165-MER)

(1)

DNA (176-MER)

(1)

DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3')

(1)

DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3')

(1)

DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3')

(1)

DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3')

(1)

DNA MADS box

(1)

DNA-binding protein RFXANK

(1)

Di-nucleosome template foward

(1)

Di-nucleosome template reverse

(1)

Exportin-1

(1)

GLY-ALA-6A0-ARG-HIS

(1)

GLYCYL-GLYCYL-GLYCINE

(1)

GTP-binding nuclear protein Ran

(1)

HC toxin

(1)

Histone H3

(1)

Histone H3.3C

(1)

Histone deacetylase RPD3

(1)

Histone-binding protein RBBP4

(1)

Largazole

(1)

MADS box dsDNA fw: AACTATTTATAAGA

(1)

MADS box dsDNA: TCTTATAAATAGT

(1)

MADS box dsDNA: TCTTATAAATAGTT

(1)

MADS box dsNA rev:TCTTATAAATAGTT

(1)

MEF2 binding site of nur77 promoter

(1)

Myocyte-specific enhancer factor 2A

(1)

Myocyte-specific enhancer factor 2B

(1)

PEPTIDIC SUBSTRATE

(1)

Paired amphipathic helix protein pst1

(1)

Paired amphipathic helix protein pst3

(1)

Ran-specific GTPase-activating protein 1

(1)

Rco1

(1)

Retinoblastoma-like protein 1

(1)

Transcriptional regulatory protein UME1

(1)

Transcriptional regulatory protein dep1

(1)

Transcriptional regulatory protein rxt2

(1)

Transcriptional regulatory protein rxt3

(1)

Transcriptional regulatory protein sds3

(1)

Trapoxin A

(1)

U2M-ASN-HYP-LYS-GLN-DLY-TRP-GLY peptide macrocycle

(1)

U2M-ASN-PRO-LYS-GLN-DLY-TRP-GLY peptide macrocycle

(1)

Uncharacterized protein C2F7.07c

(1)

Unclear peptide

(1)

alpha tubulin K40 tripeptide

(1)

histone H4 tripeptide

(1)

 

More...

Interacting ligands  (133)

ZN : ZINC ION

(204)

K : POTASSIUM ION

(130)

GOL : GLYCEROL

(56)

CA : CALCIUM ION

(37)

PEG : DI(HYDROXYETHYL)ETHER

(30)

EDO : 1,2-ETHANEDIOL

(24)

NA : SODIUM ION

(24)

DMF : DIMETHYLFORMAMIDE

(22)

SO4 : SULFATE ION

(21)

B3N : 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

(18)

PG4 : TETRAETHYLENE GLYCOL

(18)

NHE : 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID

(12)

IHP : INOSITOL HEXAKISPHOSPHATE

(10)

SHH : OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE

(10)

ACT : ACETATE ION

(8)

PGE : TRIETHYLENE GLYCOL

(8)

CL : CHLORIDE ION

(7)

TSN : TRICHOSTATIN A

(7)

MCM : 7-AMINO-4-METHYL-CHROMEN-2-ONE

(6)

NO3 : NITRATE ION

(5)

A1ACV : (1r,4r)-N~1~-[(7P)-2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl]cyclohexane-1,4-diamine

(4)

BME : BETA-MERCAPTOETHANOL

(4)

DMS : DIMETHYL SULFOXIDE

(3)

KZF : 2-(cyclohexylazaniumyl)ethanesulfonate

(3)

MG : MAGNESIUM ION

(3)

TFG : 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL

(3)

TLA : L(+)-TARTARIC ACID

(3)

CO : COBALT (II) ION

(2)

DIO : 1,4-DIETHYLENE DIOXIDE

(2)

FMT : FORMIC ACID

(2)

GKW : 1-[(4-methoxyphenyl)methyl]-~{N}-oxidanyl-indole-6-carboxamide

(2)

GM5 : ~{N}-oxidanyl-3-[1-(phenylsulfanylmethyl)-1,2,3-triazol-4-yl]benzamide

(2)

GOK : 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide

(2)

HA3 : N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide

(2)

IMD : IMIDAZOLE

(2)

IOD : IODIDE ION

(2)

PG5 : 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE

(2)

V1P : 5-{(1S)-7,7-dihydroxy-1-[(1-methylazetidine-3-carbonyl)amino]nonyl}-2-phenyl-1H-imidazole-4-carboxamide

(2)

0DI : (2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one

(1)

144 : TRIS-HYDROXYMETHYL-METHYL-AMMONIUM

(1)

1DI : (2R)-2-amino-3-(2,4-dichlorophenyl)-1-(1,3-dihydro-2H-isoindol-2-yl)propan-1-one

(1)

1PE : PENTAETHYLENE GLYCOL

(1)

20Y : 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide

(1)

2OP : (2S)-2-HYDROXYPROPANOIC ACID

(1)

4UI : 5-[[(2R)-7-fluoranyl-2-phenyl-2,3-dihydrothieno[3,2-b]indol-4-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide

(1)

4VX : 5-[[(2R)-7-bromanyl-2-phenyl-2,3-dihydrothieno[3,2-b]indol-4-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide

(1)

4WB : 5-[[(2R)-2-(3-chlorophenyl)-1'-methyl-spiro[2H-indole-3,4'-piperidine]-1-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide

(1)

4XI : 5-[[(2S)-2-(4-chlorophenyl)-1'-methyl-spiro[2H-indole-3,4'-piperidine]-1-yl]methyl]-N-oxidanyl-thiophene-2-carboxamide

(1)

5IB : ~{N}-[2-methoxy-5-(oxidanylcarbamoyl)phenyl]dibenzofuran-4-carboxamide

(1)

5OG : Belinostat

(1)

5OJ : 4-[2-[2-hydroxyethyl(phenyl)amino]-2-oxidanylidene-ethyl]-~{N}-oxidanyl-benzamide

(1)

5OK : Oxamflatin

(1)

5YA : 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide

(1)

6EZ : (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide

(1)

9F4 : (1R,2R,3R)-2-[4-(5-fluoranylpyrimidin-2-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide

(1)

9Z8 : 6-(2-Mercaptoacetylamino)-N-phenylhexanamide

(1)

AGE : (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide

(1)

BR : BROMIDE ION

(1)

C7 : N-{2-[3-(hydroxyamino)-3-oxopropyl]phenyl}-3-(trifluoromethyl)benzamide

(1)

CRI : 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4'-HYDROXYAMIDE

(1)

E7Q : ~{N}-[(3~{S})-1-(4-chlorophenyl)-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-~{N}-oxidanyl-hexanamide

(1)

EBE : (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide

(1)

EL8 : (6~{R})-6-[[3,4-bis(oxidanylidene)-2-[[4-(trifluoromethyloxy)phenyl]amino]cyclobuten-1-yl]amino]-~{N}-oxidanyl-heptanamide

(1)

FE2 : FE (II) ION

(1)

FF2 : 4-chloranyl-~{N}-oxidanyl-1-benzothiophene-2-carboxamide

(1)

FG8 : (~{E})-3-[2-(4-chlorophenyl)sulfanylphenyl]-~{N}-oxidanyl-prop-2-enamide

(1)

FGN : (~{E})-3-[2-[[2,6-bis(chloranyl)phenyl]methoxy]phenyl]-~{N}-oxidanyl-prop-2-enamide

(1)

FKS : 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol

(1)

GGG : glycylglycylglycine

(1)

GLC : alpha-D-glucopyranose

(1)

GOW : 3-benzamido-4-methyl-~{N}-oxidanyl-benzamide

(1)

GQE : 3-benzamido-4-methoxy-~{N}-oxidanyl-benzamide

(1)

GQN : 4-methoxy-~{N}-oxidanyl-3-[(4-phenylphenyl)carbonylamino]benzamide

(1)

GQW : ~{N}-[2-chloranyl-5-(oxidanylcarbamoyl)phenyl]-1-benzothiophene-7-carboxamide

(1)

GQZ : ~{N}1-oxidanyl-~{N}3-phenyl-benzene-1,3-dicarboxamide

(1)

GRK : 4-methoxy-~{N}-oxidanyl-3-(2-phenylethanoylamino)benzamide

(1)

GRZ : 1-[5-chloranyl-2-(4-fluoranylphenoxy)phenyl]-~{N}-oxidanyl-1,2,3-triazole-4-carboxamide

(1)

GT2 : 4-chloranyl-3-[(2,4-dichlorophenyl)carbonylamino]-~{N}-oxidanyl-benzamide

(1)

I0P : D-MYO INOSITOL 1,4,5,6 TETRAKISPHOSPHATE

(1)

IWX : N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide

(1)

J38 : (2R)-2-methyl-3-oxo-4H-1,4-benzothiazine-6-carbohydroxamic acid

(1)

KEE : (1R,2R,3R)-2-[4-(1,3-oxazol-5-yl)phenyl]-N-oxidanyl-3-phenyl-cyclopropane-1-carboxamide

(1)

KIZ : [(2~{R})-1-(dimethylamino)-3-(4-fluorophenyl)-1-oxidanylidene-propan-2-yl]azanium

(1)

KJ6 : 6-methyl-4-oxidanyl-pyran-2-one

(1)

KJF : [(2~{R})-1-oxidanylidene-4-phenyl-1-pyrrolidin-1-yl-butan-2-yl]azanium

(1)

KJN : [(2~{R})-1-(dimethylamino)-1-oxidanylidene-4-phenyl-butan-2-yl]azanium

(1)

KK0 : (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one

(1)

KKI : 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile

(1)

KKW : [(2~{R},4~{S})-4-(3-chlorophenyl)pyrrolidin-2-yl]-(4-thieno[2,3-c]pyridin-7-ylpiperazin-1-yl)methanone

(1)

KMY : 3-chlorobenzothiophene-2-carbohydroxamic acid

(1)

KRU : 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone

(1)

L6G : (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3,17-dithia-7,10,14,19,20-pentaazatricyclo[14.2.1.1~2,5~]icosa-1(18),2(20),16(19)-triene-6,9,13-trione

(1)

L7G : (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,17,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione

(1)

L8G : (5R,8S,11S)-5-methyl-8-(propan-2-yl)-11-[(1E)-4-sulfanylbut-1-en-1-yl]-3-thia-7,10,14,20,21-pentaazatricyclo[14.3.1.1~2,5~]henicosa-1(20),2(21),16,18-tetraene-6,9,13-trione

(1)

LBH : Panobinostat

(1)

LLX : N-(4-aminobiphenyl-3-yl)benzamide

(1)

M7Y : (2E)-3-[2-(3-cyclopentyl-5,5-dimethyl-2-oxoimidazolidin-1-yl)phenyl]-N-hydroxyprop-2-enamide

(1)

M8G : N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide

(1)

MN : MANGANESE (II) ION

(1)

NH4 : AMMONIUM ION

(1)

 

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EC number / name  (1)

3.5.1.98 : Histone deacetylase

(228)

Biological function  (46)

histone deacetylase activity

(174)

histone deacetylase activity, hydrolytic mechanism

(109)

hydrolase activity

(109)

protein binding

(109)

metal ion binding

(99)

protein lysine deacetylase activity

(78)

DNA-binding transcription factor binding

(75)

histone decrotonylase activity

(75)

protein decrotonylase activity

(75)

Hsp70 protein binding

(53)

Hsp90 protein binding

(53)

transcription corepressor activity

(34)

zinc ion binding

(30)

chromatin binding

(26)

transcription coactivator activity

(25)

NF-kappaB binding

(22)

RNA polymerase II-specific DNA-binding transcription factor binding

(22)

enzyme binding

(22)

histone deacetylase binding

(22)

nucleosomal DNA binding

(22)

promoter-specific chromatin binding

(22)

protein lysine delactylase activity

(22)

RNA binding

(13)

deacetylase activity

(13)

heat shock protein binding

(13)

histone binding

(13)

protein de-2-hydroxyisobutyrylase activity

(13)

transcription coregulator binding

(13)

DNA binding

(9)

E-box binding

(9)

Krueppel-associated box domain binding

(9)

RNA polymerase II cis-regulatory region sequence-specific DNA binding

(9)

RNA polymerase II core promoter sequence-specific DNA binding

(9)

core promoter sequence-specific DNA binding

(9)

p53 binding

(9)

transcription cis-regulatory region binding

(9)

transcription corepressor binding

(9)

histone H3K14 deacetylase activity, hydrolytic mechanism

(4)

identical protein binding

(4)

histone H3K9 deacetylase activity, hydrolytic mechanism

(3)

histone H4K12 deacetylase activity, hydrolytic mechanism

(3)

histone H4K16 deacetylase activity, hydrolytic mechanism

(3)

histone H4K5 deacetylase activity, hydrolytic mechanism

(3)

histone H4K8 deacetylase activity, hydrolytic mechanism

(3)

carbohydrate transmembrane transporter activity

(1)

maltose binding

(1)

Biological process  (113)

chromatin organization

(145)

heterochromatin formation

(139)

negative regulation of transcription by RNA polymerase II

(104)

mitotic sister chromatid cohesion

(53)

negative regulation of protein ubiquitination

(53)

regulation of protein stability

(53)

regulation of telomere maintenance

(53)

positive regulation of transcription by RNA polymerase II

(51)

epigenetic regulation of gene expression

(44)

cellular response to heat

(38)

regulation of transcription by RNA polymerase II

(34)

positive regulation of macromolecule biosynthetic process

(29)

regulation of DNA-templated transcription

(29)

G1/S transition of mitotic cell cycle

(25)

G2/M transition of mitotic cell cycle

(25)

cellular response to nitrogen starvation

(25)

meiotic cell cycle

(25)

negative regulation of rDNA heterochromatin formation

(25)

negative regulation of reciprocal meiotic recombination

(25)

negative regulation of silent mating-type cassette heterochromatin formation

(25)

negative regulation of transcription by RNA polymerase I

(25)

nucleophagy

(25)

nucleosome assembly

(25)

positive regulation of macroautophagy

(25)

protein localization to nucleolar rDNA repeats

(25)

rDNA chromatin condensation

(25)

regulation of DNA-templated DNA replication initiation

(25)

response to oxidative stress

(25)

transcription elongation by RNA polymerase II

(25)

chromatin remodeling

(22)

circadian regulation of gene expression

(22)

embryonic digit morphogenesis

(22)

epidermal cell differentiation

(22)

eyelid development in camera-type eye

(22)

fungiform papilla formation

(22)

hair follicle placode formation

(22)

negative regulation of DNA-templated transcription

(22)

negative regulation of apoptotic process

(22)

negative regulation of cell migration

(22)

negative regulation of stem cell population maintenance

(22)

negative regulation of transforming growth factor beta receptor signaling pathway

(22)

odontogenesis of dentin-containing tooth

(22)

positive regulation of DNA-templated transcription

(22)

positive regulation of cell population proliferation

(22)

positive regulation of intracellular estrogen receptor signaling pathway

(22)

positive regulation of oligodendrocyte differentiation

(22)

positive regulation of stem cell population maintenance

(22)

regulation of cell fate specification

(22)

regulation of stem cell differentiation

(22)

rhythmic process

(22)

behavioral response to ethanol

(13)

cardiac muscle hypertrophy

(13)

cellular response to dopamine

(13)

cellular response to hydrogen peroxide

(13)

cellular response to retinoic acid

(13)

cellular response to transforming growth factor beta stimulus

(13)

dendrite development

(13)

negative regulation of dendritic spine development

(13)

negative regulation of neuron projection development

(13)

negative regulation of transcription by competitive promoter binding

(13)

positive regulation of epithelial to mesenchymal transition

(13)

positive regulation of interleukin-1 production

(13)

positive regulation of male mating behavior

(13)

positive regulation of proteolysis

(13)

positive regulation of tumor necrosis factor production

(13)

progesterone receptor signaling pathway

(13)

protein modification process

(13)

response to alcohol

(13)

response to amphetamine

(13)

response to amyloid-beta

(13)

response to caffeine

(13)

response to cocaine

(13)

response to hyperoxia

(13)

response to lipopolysaccharide

(13)

response to nicotine

(13)

response to xenobiotic stimulus

(13)

DNA methylation-dependent constitutive heterochromatin formation

(9)

cellular response to platelet-derived growth factor stimulus

(9)

circadian rhythm

(9)

endoderm development

(9)

hippocampus development

(9)

negative regulation by host of viral transcription

(9)

negative regulation of androgen receptor signaling pathway

(9)

negative regulation of canonical NF-kappaB signal transduction

(9)

negative regulation of canonical Wnt signaling pathway

(9)

negative regulation of gene expression

(9)

negative regulation of gene expression, epigenetic

(9)

negative regulation of intrinsic apoptotic signaling pathway

(9)

negative regulation of myotube differentiation

(9)

neuron differentiation

(9)

oligodendrocyte differentiation

(9)

positive regulation of gene expression

(9)

positive regulation of smooth muscle cell proliferation

(9)

protein deacetylation

(9)

negative regulation of transcription by transcription factor localization

(4)

regulation of gene expression

(4)

transcription initiation-coupled chromatin remodeling

(3)

DNA damage response

(1)

carbohydrate transmembrane transport

(1)

carbohydrate transport

(1)

 

More...

Biological cell component  (38)

nucleus

(145)

histone deacetylase complex

(108)

cytoplasm

(100)

nucleoplasm

(75)

chromosome

(54)

nuclear chromosome

(53)

Sin3-type complex

(47)

Rpd3L complex

(28)

Rpd3L-Expanded complex

(28)

Rpd3S complex

(28)

chromatin

(26)

Snt2C complex

(25)

nuclear periphery

(25)

NuRD complex

(22)

protein-containing complex

(22)

chromosome, telomeric region

(14)

ESC/E(Z) complex

(13)

cytosol

(12)

heterochromatin

(9)

neuronal cell body

(9)

transcription regulator complex

(9)

transcription repressor complex

(9)

HDA1 complex

(4)

nucleolus

(4)

ATP-binding cassette (ABC) transporter complex

(1)

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

(1)

SHREC complex

(1)

chromosome, centromeric region

(1)

euchromatin

(1)

heterochromatin island

(1)

maltose transport complex

(1)

mating-type region heterochromatin

(1)

membrane

(1)

outer membrane-bounded periplasmic space

(1)

pericentric heterochromatin

(1)

periplasmic space

(1)

rDNA heterochromatin

(1)

subtelomeric heterochromatin

(1)

SCOP fold  (1)

Arginase/deacetylase

(8)

Representative Structures

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