› 152d

X-ray diffraction
1.4Å resolution

DIVERSITY OF WATER RING SIZE AT DNA INTERFACES: HYDRATION AND DYNAMICS OF DNA-ANTHRACYCLINE COMPLEXES

Released:
DOI: 10.2210/pdb152d/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 152d coloured by chain, front view.
PDB entry 152d coloured by chain, side view.
PDB entry 152d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Water ring structure at DNA interfaces: hydration and dynamics of DNA-anthracycline complexes.
Lipscomb LA, Peek ME, Zhou FX, Bertrand JA, VanDerveer D, Williams LD
Biochemistry 33 3649-59 (1994)
PMID: 8142363

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113341 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*AP*TP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM1 1 x DM1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 27.85Å b: 27.85Å c: 52.33Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 not available not available
Expression system: Not provided

Quick links

Citations

5 review citations

Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action.
Shaaban et al. (2014)
4 more

9 mentions without citation

Structure-based drug design: from nucleic acid to membrane protein targets.
Dailey et al. (2009)
8 more