› 159d

X-ray diffraction
1.8Å resolution

SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX

Released:
DOI: 10.2210/pdb159d/pdb
PDB entry 159d coloured by chain, front view.
PDB entry 159d coloured by chain, side view.
PDB entry 159d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex.
Chen X, Ramakrishnan B, Rao ST, Sundaralingam M
Nat Struct Biol 1 169-75 (1994)
PMID: 7656035

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113346 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*IP*CP*IP*CP*IP*CP*IP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.37 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand DMY 1 x DMY
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P4122
Unit cell:
a: 27.93Å b: 27.93Å c: 57.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.15 not available
Expression system: Not provided

Quick links

Citations

8 review citations

Targeting the minor groove of DNA.
Wemmer et al. (1997)
7 more

4 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
3 more