› 173d

X-ray diffraction
3Å resolution

MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA

Released:
DOI: 10.2210/pdb173d/pdb
PDB entry 173d coloured by chain, front view.
PDB entry 173d coloured by chain, side view.
PDB entry 173d coloured by chain, top view.
Source organism: Streptomyces antibioticus
Primary publication:
Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of D(Gaagcttc)2-Actinomycin D Complexes and its Host DNA
Kamitori S, Takusagawa F
J. Am. Chem. Soc. 116 4154- (1994)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-113352 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
ACTINOMYCIN D Chains: C, D
Molecule details ›
Chains: C, D
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Streptomyces antibioticus
DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Streptomyces antibioticus
Expression system: Not provided

Ligands and Environments

No bound ligands
3 modified residues:
Ligand DVA 4 x DVA
Ligand SAR 4 x SAR
Ligand MVA 4 x MVA

Experiments and Validation Details

Entry percentile scores
Spacegroup: F222
Unit cell:
a: 69.9Å b: 61.41Å c: 54.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 not available
Expression system: Not provided

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