› 185d

Solution NMR

SEQUENCE SPECIFICITY OF QUINOXALINE ANTIBIOTICS. 1. SOLUTION STRUCTURE OF A 1:1 COMPLEX BETWEEN TRIOSTIN A AND [D(GACGTC)]2 AND COMPARISON WITH THE SOLUTION STRUCTURE OF THE [N-MECYS3, N-MECYS7]TANDEM-[D(GATATC)]2 COMPLEX

Released:
DOI: 10.2210/pdb185d/pdb
PDB entry 185d coloured by chain, ensemble of 5 models, front view.
PDB entry 185d coloured by chain, ensemble of 5 models, side view.
PDB entry 185d coloured by chain, ensemble of 5 models, top view.
Source organism: Streptomyces sp.
Primary publication:
Sequence specificity of quinoxaline antibiotics. 1. Solution structure of a 1:1 complex between triostin A and [d(GACGTC)]2 and comparison with the solution structure of the [N-MeCys3,N-MeCys7]TANDEM-[d(GATATC)]2 complex.
Addess KJ, Feigon J
Biochemistry 33 12386-96 (1994)
PMID: 7918461

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-113363 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
TRIOSTIN A Chain: A
Molecule details ›
Chain: A
Length: 8 amino acids
Theoretical weight: 795 Da
Source organism: Streptomyces sp.
Expression system: Not provided
DNA (5'-D(*GP*AP*CP*GP*TP*C)-3') Chains: C, D
Molecule details ›
Chains: C, D
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Streptomyces sp.
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand QUI 2 x QUI
2 modified residues:
Ligand DSN 2 x DSN
Ligand MVA 2 x MVA

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

1 review citation

Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.
Dawson et al. (2007)
13 other articles

2 mentions without citation

Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.
Lolli G. (2009)
1 more