› 1a0m

X-ray diffraction
1.1Å resolution

1.1 ANGSTROM CRYSTAL STRUCTURE OF A-CONOTOXIN [TYR15]-EPI

Released:
DOI: 10.2210/pdb1a0m/pdb
PDB entry 1a0m coloured by chain, front view.
PDB entry 1a0m coloured by chain, side view.
PDB entry 1a0m coloured by chain, top view.
Source organism: Conus episcopatus
Primary publication:
The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods.
Hu SH, Loughnan M, Miller R, Weeks CM, Blessing RH, Alewood PF, Lewis RJ, Martin JL
Biochemistry 37 11425-33 (1998)
PMID: 9708977

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157510 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin EpI Chains: A, B
Molecule details ›
Chains: A, B
Length: 17 amino acids
Theoretical weight: 1.79 KDa
Source organism: Conus episcopatus
Expression system: Not provided
UniProt:
  • Canonical: P56638 (Residues: 40-55; Coverage: 40%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: I4
Unit cell:
a: 44.4Å b: 44.4Å c: 23.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.161 0.178
Expression system: Not provided

Quick links

Citations

6 review citations

Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes.
McIntosh et al. (1999)
5 more

4 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
3 more