› 1a1t

Solution NMR

STRUCTURE OF THE HIV-1 NUCLEOCAPSID PROTEIN BOUND TO THE SL3 PSI-RNA RECOGNITION ELEMENT, NMR, 25 STRUCTURES

Released:
DOI: 10.2210/pdb1a1t/pdb
PDB entry 1a1t coloured by chain, ensemble of 25 models, front view.
PDB entry 1a1t coloured by chain, ensemble of 25 models, side view.
PDB entry 1a1t coloured by chain, ensemble of 25 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element.
De Guzman RN, Wu ZR, Stalling CC, Pappalardo L, Borer PN, Summers MF
Science 279 384-8 (1998)
PMID: 9430589

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181102 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
CCHC-type domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 6.39 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q75677 (Residues: 1-55; Coverage: 51%)
Gene name: gag
Sequence domains: Zinc knuckle
Structure domains: Zinc finger, CCHC-type
SL3 STEM-LOOP RNA Chain: B
Molecule details ›
Chain: B
Length: 20 nucleotides
Theoretical weight: 6.48 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

73 review citations

Zinc finger proteins: new insights into structural and functional diversity.
Laity et al. (2001)
72 more

37 mentions without citation

Engineering RNA-binding proteins for biology.
Chen et al. (2013)
36 more