› 1a2a

X-ray diffraction
2.8Å resolution

AGKISTROTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS

Released:
DOI: 10.2210/pdb1a2a/pdb
Model geometry
Fit model/data
PDB entry 1a2a coloured by chain, front view.
PDB entry 1a2a coloured by chain, side view.
PDB entry 1a2a coloured by chain, top view.
Source organism: Gloydius halys
Primary publication:
Crystal structure of agkistrodotoxin, a phospholipase A2-type presynaptic neurotoxin from agkistrodon halys pallas.
Tang L, Zhou YC, Lin ZJ
J Mol Biol 282 1-11 (1998)
PMID: 9733637

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutral phospholipase A2 agkistrodotoxin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 122 amino acids
Theoretical weight: 13.87 KDa
Source organism: Gloydius halys
UniProt:
  • Canonical: P14421 (Residues: 1-122; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RUH2R
Spacegroup: P21
Unit cell:
a: 108.95Å b: 85.227Å c: 71.054Å
α: 90° β: 109.66° γ: 90°
R-values:
R R work R free
0.207 0.207 0.285

Quick links

Citations

2 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
1 more

2 mentions without citation

Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics.
Faure et al. (2007)
1 more