› 1a3m

Solution NMR

PAROMOMYCIN BINDING INDUCES A LOCAL CONFORMATIONAL CHANGE IN THE A SITE OF 16S RRNA, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1a3m/pdb
PDB entry 1a3m coloured by chain, ensemble of 20 models, front view.
PDB entry 1a3m coloured by chain, ensemble of 20 models, side view.
PDB entry 1a3m coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA.
Fourmy D, Yoshizawa S, Puglisi JD
J Mol Biol 277 333-45 (1998)
PMID: 9514734

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195949 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
16S RRNA (5'-R(*GP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*UP*UP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 14 nucleotides
Theoretical weight: 4.4 KDa
Source organism: Synthetic construct
Expression system: Not provided
16S RRNA (5'-R(*GP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 13 nucleotides
Theoretical weight: 4.21 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Expression system: Not provided

Quick links

Citations

35 review citations

Structural insights into translational fidelity.
Ogle et al. (2005)
34 more

3 mentions without citation

Molecular dynamics study of the ribosomal A-site.
Romanowska et al. (2008)
2 more