› 1a3n

X-ray diffraction
1.8Å resolution

DEOXY HUMAN HEMOGLOBIN

Released:
DOI: 10.2210/pdb1a3n/pdb
PDB entry 1a3n coloured by chain, front view.
PDB entry 1a3n coloured by chain, side view.
PDB entry 1a3n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structures of deoxy human haemoglobin and the mutant Hb Tyralpha42His at 120 K.
Tame JR, Vallone B
Acta Crystallogr D Biol Crystallogr 56 805-11 (2000)
PMID: 10930827

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

1 bound ligand:
Ligand HEM 4 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 62.65Å b: 82.43Å c: 53.53Å
α: 90° β: 99.61° γ: 90°
R-values:
R R work R free
0.171 0.171 0.22

Quick links

Citations

1 review citation

X-ray crystallography and sickle cell disease drug discovery-a tribute to Donald Abraham.
Donkor et al. (2023)
17 other articles

51 mentions without citation

Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation.
Bahar et al. (2007)
50 more