› 1a4p

X-ray diffraction
2.25Å resolution

P11 (S100A10), LIGAND OF ANNEXIN II

Released:
DOI: 10.2210/pdb1a4p/pdb
PDB entry 1a4p coloured by chain, front view.
PDB entry 1a4p coloured by chain, side view.
PDB entry 1a4p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of a complex of p11 with the annexin II N-terminal peptide.
Réty S, Sopkova J, Renouard M, Osterloh D, Gerke V, Tabaries S, Russo-Marie F, Lewit-Bentley A
Nat Struct Biol 6 89-95 (1999)
PMID: 9886297

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158126 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 96 amino acids
Theoretical weight: 11.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P60903 (Residues: 2-97; Coverage: 99%)
Gene names: ANX2LG, CAL1L, CLP11, S100A10
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE D41A
Spacegroup: I222
Unit cell:
a: 57.75Å b: 80.75Å c: 95.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.227 0.303
Expression system: Escherichia coli BL21

Quick links

Citations

46 review citations

Annexins: from structure to function.
Gerke et al. (2002)
45 more

5 mentions without citation

In silico structure-based approaches to discover protein-protein interaction-targeting drugs.
Shin et al. (2017)
4 more