› 1a6p

X-ray diffraction
2.08Å resolution

ENGINEERING OF A MISFOLDED FORM OF CD2

Released:
DOI: 10.2210/pdb1a6p/pdb
PDB entry 1a6p coloured by chain, front view.
PDB entry 1a6p coloured by chain, side view.
PDB entry 1a6p coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Engineering an intertwined form of CD2 for stability and assembly.
Murray AJ, Head JG, Barker JJ, Brady RL
Nat Struct Biol 5 778-82 (1998)
PMID: 9731771

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140435 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell surface antigen CD2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 94 amino acids
Theoretical weight: 10.54 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P08921 (Residues: 26-121; Coverage: 29%)
Gene name: Cd2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P43
Unit cell:
a: 41.09Å b: 41.09Å c: 105.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.296
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Deposition diseases and 3D domain swapping.
Bennett et al. (2006)
4 more

2 mentions without citation

Interpreting functional effects of coding variants: challenges in proteome-scale prediction, annotation and assessment.
Shameer et al. (2016)
1 more