› 1adi

X-ray diffraction
2.5Å resolution

STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE AT PH 6.5 AND 25 DEGREES CELSIUS

Released:
DOI: 10.2210/pdb1adi/pdb
PDB entry 1adi coloured by chain, front view.
PDB entry 1adi coloured by chain, side view.
PDB entry 1adi coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli.
Silva MM, Poland BW, Hoffman CR, Fromm HJ, Honzatko RB
J Mol Biol 254 431-46 (1995)
PMID: 7490761

Function and Biology Details

Reaction catalysed: 
GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylosuccinate synthetase Chains: A, B
Molecule details ›
Chains: A, B
Length: 431 amino acids
Theoretical weight: 47.27 KDa
Source organism: Escherichia coli
UniProt:
  • Canonical: P0A7D4 (Residues: 2-432; Coverage: 100%)
Gene names: JW4135, adeK, b4177, purA
Sequence domains: Adenylosuccinate synthetase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 73.42Å b: 93.63Å c: 119.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 not available

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Citations

1 review citation

Structure-function studies of adenylosuccinate synthetase from Escherichia coli.
Honzatko et al. (1999)
12 other articles