› 1aff

Solution NMR

DNA QUADRUPLEX CONTAINING GGGG TETRADS AND (T.A).A TRIADS, NMR, 8 STRUCTURES

Released:
DOI: 10.2210/pdb1aff/pdb
PDB entry 1aff coloured by chain, ensemble of 8 models, front view.
PDB entry 1aff coloured by chain, ensemble of 8 models, side view.
PDB entry 1aff coloured by chain, ensemble of 8 models, top view.
Source organism: Synthetic construct
Primary publication:
Bombyx mori single repeat telomeric DNA sequence forms a G-quadruplex capped by base triads.
Kettani A, Bouaziz S, Wang W, Jones RA, Patel DJ
Nat Struct Biol 4 382-9 (1997)
PMID: 9145109

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113412 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
QUADRUPLEX DNA (5'-D(TP*AP*GP*G)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 4 nucleotides
Theoretical weight: 1.23 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY AND SIMULATED ANNEALING, DISTANCE RESTRAINED MOLECULAR DYNAMICS REFINEMENT AND RELAXATION MATRIX INTENSITY REFINEMENT
Expression system: Not provided

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Citations

9 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
8 more