› 1ag7

Solution NMR

CONOTOXIN GS, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1ag7/pdb
PDB entry 1ag7 coloured by chain, ensemble of 20 models, front view.
PDB entry 1ag7 coloured by chain, ensemble of 20 models, side view.
PDB entry 1ag7 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus geographus
Primary publication:
Solution structure of the sodium channel antagonist conotoxin GS: a new molecular caliper for probing sodium channel geometry.
Hill JM, Alewood PF, Craik DJ
Structure 5 571-83 (1997)
PMID: 9115446

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-conotoxin GS Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.63 KDa
Source organism: Conus geographus
Expression system: Not provided
UniProt:
  • Canonical: P15472 (Residues: 1-34; Coverage: 100%)
Sequence domains: Conotoxin TVIIA/GS family

Ligands and Environments

No bound ligands
2 modified residues:
Ligand HYP 2 x HYP
Ligand CGU 1 x CGU

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

The cystine knot motif in toxins and implications for drug design.
Craik et al. (2001)
5 more

4 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
3 more