› 1aio

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN

Released:
DOI: 10.2210/pdb1aio/pdb
PDB entry 1aio coloured by chain, front view.
PDB entry 1aio coloured by chain, side view.
PDB entry 1aio coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.
Takahara PM, Rosenzweig AC, Frederick CA, Lippard SJ
Nature 377 649-52 (1995)
PMID: 7566180

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113423 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*CP*CP*(BRU)P*CP*TP*[PT(NH3)2(GP*GP)]*TP*CP*TP*CP*C)-3') Chains: A, C
Molecule details ›
Chains: A, C
Length: 12 nucleotides
Theoretical weight: 3.63 KDa
Source organism: Unidentified
Expression system: Not provided
DNA (5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3') Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 nucleotides
Theoretical weight: 3.76 KDa
Source organism: Unidentified
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CPT 2 x CPT
1 modified residue:
Ligand BRU 2 x BRU

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 31.27Å b: 35.46Å c: 47.01Å
α: 79.81° β: 84.75° γ: 82.79°
R-values:
R R work R free
0.206 0.206 0.251
Expression system: Not provided

Quick links

Citations

42 review citations

The resurgence of platinum-based cancer chemotherapy.
Kelland L. (2007)
41 more

18 mentions without citation

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.
Johnstone et al. (2016)
17 more