› 1ajj

X-ray diffraction
1.7Å resolution

LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING

Released:
DOI: 10.2210/pdb1ajj/pdb
PDB entry 1ajj coloured by chain, front view.
PDB entry 1ajj coloured by chain, side view.
PDB entry 1ajj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.
Fass D, Blacklow S, Kim PS, Berger JM
Nature 388 691-3 (1997)
PMID: 9262405

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P01130 (Residues: 196-232; Coverage: 4%)
Gene name: LDLR
Sequence domains: Low-density lipoprotein receptor domain class A

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: R3
Unit cell:
a: 53.45Å b: 53.45Å c: 26.76Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.209 0.24
Expression system: Escherichia coli BL21

Quick links

Citations

42 review citations

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.
Lillis et al. (2008)
41 more

36 mentions without citation

Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers.
Blacklow SC. (2007)
35 more