› 1ap4

Solution NMR

REGULATORY DOMAIN OF HUMAN CARDIAC TROPONIN C IN THE CALCIUM-SATURATED STATE, NMR, 40 STRUCTURES

Released:
DOI: 10.2210/pdb1ap4/pdb
PDB entry 1ap4 coloured by chain, ensemble of 40 models, front view.
PDB entry 1ap4 coloured by chain, ensemble of 40 models, side view.
PDB entry 1ap4 coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.
Spyracopoulos L, Li MX, Sia SK, Gagné SM, Chandra M, Solaro RJ, Sykes BD
Biochemistry 36 12138-46 (1997)
PMID: 9315850

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Regulation of contraction in striated muscle.
Gordon et al. (2000)
23 more

22 mentions without citation

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs.
Li et al. (2015)
21 more