› 1as5

Solution NMR

SOLUTION STRUCTURE OF CONOTOXIN Y-PIIIE FROM CONUS PURPURASCENS, NMR, 14 STRUCTURES

Released:
DOI: 10.2210/pdb1as5/pdb
PDB entry 1as5 coloured by chain, ensemble of 14 models, front view.
PDB entry 1as5 coloured by chain, ensemble of 14 models, side view.
PDB entry 1as5 coloured by chain, ensemble of 14 models, top view.
Source organism: Conus purpurascens
Primary publication:
Three-dimensional solution structure of conotoxin psi-PIIIE, an acetylcholine gated ion channel antagonist.
Mitchell SS, Shon KJ, Foster MP, Davis DR, Olivera BM, Ireland CM
Biochemistry 37 1215-20 (1998)
PMID: 9477946

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Psi-conotoxin PIIIE Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.73 KDa
Source organism: Conus purpurascens
Expression system: Not provided
UniProt:
  • Canonical: P56529 (Residues: 51-73; Coverage: 41%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 3 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING COMBINED WITH IRMA
Expression system: Not provided

Quick links

Citations

4 review citations

Conus venoms: a rich source of novel ion channel-targeted peptides.
Terlau et al. (2004)
3 more

2 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
1 more