› 1au5

Solution NMR

SOLUTION STRUCTURE OF INTRASTRAND CISPLATIN-CROSSLINKED DNA OCTAMER D(CCTG*G*TCC):D(GGACCAGG), NMR, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1au5/pdb
PDB entry 1au5 coloured by chain, front view.
PDB entry 1au5 coloured by chain, side view.
PDB entry 1au5 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structure and isomerization of an intrastrand cisplatin-cross-linked octamer DNA duplex by NMR analysis.
Yang D, van Boom SS, Reedijk J, van Boom JH, Wang AH
Biochemistry 34 12912-20 (1995)
PMID: 7548048

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113438 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*CP*CP*TP*GP*GP*TP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 8 nucleotides
Theoretical weight: 2.38 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*GP*AP*CP*CP*AP*GP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 8 nucleotides
Theoretical weight: 2.48 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CPT 1 x CPT
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RESTRAINED REFINEMENT SPEDREF
Expression system: Not provided

Quick links

Citations

7 review citations

Inhibition of transcription by platinum antitumor compounds.
Todd et al. (2009)
6 more

3 mentions without citation

New Insights on the Interaction of Phenanthroline Based Ligands and Metal Complexes and Polyoxometalates with Duplex DNA and G-Quadruplexes.
Sánchez-González et al. (2021)
2 more