› 1au6

Solution NMR

SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE

Released:
DOI: 10.2210/pdb1au6/pdb
PDB entry 1au6 coloured by chain, front view.
PDB entry 1au6 coloured by chain, side view.
PDB entry 1au6 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA.
Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH
Nat Struct Biol 2 577-8 (1995)
PMID: 7664126

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113439 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 8 nucleotides
Theoretical weight: 2.43 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BPT 1 x BPT
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RESTRAINED REFINEMENT SPEDREF
Expression system: Not provided

Quick links

Citations

4 review citations

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.
Johnstone et al. (2016)
3 more

1 mention without citation

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors.
Jeddi et al. (2017)