› 1axt

X-ray diffraction
2.15Å resolution

IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES

Released:
DOI: 10.2210/pdb1axt/pdb
PDB entry 1axt coloured by chain, front view.
PDB entry 1axt coloured by chain, side view.
PDB entry 1axt coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope.
Barbas CF, Heine A, Zhong G, Hoffmann T, Gramatikova S, Björnestedt R, List B, Anderson J, Stura EA, Wilson IA, Lerner RA
Science 278 2085-92 (1997)
PMID: 9405338

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-224992 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN IGG2A Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 23.8 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Ig gamma-2A chain C region, membrane-bound form Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01865 (Residues: 1-99; Coverage: 25%)
Gene name: Igh-1a
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 56.5Å b: 65.3Å c: 132.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 not available 0.317

Quick links

Citations

40 review citations

Strategies for development of Dengue virus inhibitors.
Noble et al. (2010)
39 more

6 mentions without citation

Protein Assembly by Design.
Zhu et al. (2021)
5 more