› 1b7d

X-ray diffraction
1.73Å resolution

NEUROTOXIN (TS1) FROM BRAZILIAN SCORPION TITYUS SERRULATUS

Released:
DOI: 10.2210/pdb1b7d/pdb
PDB entry 1b7d coloured by chain, front view.
PDB entry 1b7d coloured by chain, side view.
PDB entry 1b7d coloured by chain, top view.
Source organism: Tityus serrulatus
Primary publication:
Crystal structure of neurotoxin Ts1 from Tityus serrulatus provides insights into the specificity and toxicity of scorpion toxins.
Polikarpov I, Junior MS, Marangoni S, Toyama MH, Teplyakov A
J Mol Biol 290 175-84 (1999)
PMID: 10388565

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-mammal/insect toxin Ts1 Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.9 KDa
Source organism: Tityus serrulatus
UniProt:
  • Canonical: P15226 (Residues: 21-81; Coverage: 95%)
Sequence domains: Scorpion toxin-like domain
Structure domains: Knottin, scorpion toxin-like

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P21
Unit cell:
a: 22.21Å b: 36.54Å c: 31.72Å
α: 90° β: 100.76° γ: 90°
R-values:
R R work R free
0.178 0.178 0.238

Quick links

Citations

3 review citations

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution.
Rodríguez de la Vega et al. (2005)
2 more

3 mentions without citation

Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke.
Rohde et al. (2017)
2 more