› 1b98

X-ray diffraction
2.75Å resolution

NEUROTROPHIN 4 (HOMODIMER)

Released:
DOI: 10.2210/pdb1b98/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1b98 coloured by chain, front view.
PDB entry 1b98 coloured by chain, side view.
PDB entry 1b98 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
Robinson RC, Radziejewski C, Spraggon G, Greenwald J, Kostura MR, Burtnick LD, Stuart DI, Choe S, Jones EY
Protein Sci 8 2589-97 (1999)
PMID: 10631974

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotrophin-4 Chains: A, M
Molecule details ›
Chains: A, M
Length: 130 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P34130 (Residues: 81-210; Coverage: 70%)
Gene names: NTF4, NTF5
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL1-5
Spacegroup: P21
Unit cell:
a: 43.8Å b: 50.8Å c: 53Å
α: 90° β: 109.4° γ: 90°
R-values:
R R work R free
0.235 0.235 0.336
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Neurotrophins: roles in neuronal development and function.
Huang et al. (2001)
12 more

4 mentions without citation

Protein-protein docking benchmark version 4.0.
Hwang et al. (2010)
3 more