› 1bah

Solution NMR

A TWO DISULFIDE DERIVATIVE OF CHARYBDOTOXIN WITH DISULFIDE 13-33 REPLACED BY TWO ALPHA-AMINOBUTYRIC ACIDS, NMR, 30 STRUCTURES

Released:
DOI: 10.2210/pdb1bah/pdb
PDB entry 1bah coloured by chain, ensemble of 30 models, front view.
PDB entry 1bah coloured by chain, ensemble of 30 models, side view.
PDB entry 1bah coloured by chain, ensemble of 30 models, top view.
Source organism: Leiurus quinquestriatus
Primary publication:
NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing.
Song J, Gilquin B, Jamin N, Drakopoulou E, Guenneugues M, Dauplais M, Vita C, Ménez A
Biochemistry 36 3760-6 (1997)
PMID: 9092804

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146605 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel toxin alpha-KTx 1.1 Chain: A
Molecule details ›
Chain: A
Length: 37 amino acids
Theoretical weight: 4.27 KDa
Source organism: Leiurus quinquestriatus
Expression system: Not provided
UniProt:
  • Canonical: P13487 (Residues: 23-59; Coverage: 100%)
Sequence domains: Scorpion short toxin, BmKK2

Ligands and Environments

No bound ligands
2 modified residues:
Ligand PCA 1 x PCA
Ligand ABA 2 x ABA

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

4 review citations

Uniquely folded mini-protein motifs.
Imperiali et al. (1999)
3 more

2 mentions without citation

Peptide toxins and small-molecule blockers of BK channels.
Yu et al. (2016)
1 more