› 1bai

X-ray diffraction
2.4Å resolution

Crystal structure of Rous sarcoma virus protease in complex with inhibitor

Released:
DOI: 10.2210/pdb1bai/pdb
PDB entry 1bai coloured by chain, front view.
PDB entry 1bai coloured by chain, side view.
PDB entry 1bai coloured by chain, top view.
Source organism: Rous sarcoma virus
Primary publication:
Structural basis for specificity of retroviral proteases.
Wu J, Adomat JM, Ridky TW, Louis JM, Leis J, Harrison RW, Weber IT
Biochemistry 37 4518-26 (1998)
PMID: 9521772

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protease p15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.65 KDa
Source organism: Rous sarcoma virus
UniProt:
  • Canonical: P03322 (Residues: 578-701; Coverage: 18%)
Gene name: gag
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand 0Q4 1 x 0Q4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P65
Unit cell:
a: 62.61Å b: 62.61Å c: 132.15Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.175 0.293

Quick links

Citations

2 review citations

HIV Protease: Historical Perspective and Current Research.
Weber et al. (2021)
1 more

7 mentions without citation

Inhibition of human endogenous retrovirus-K by antiretroviral drugs.
Tyagi et al. (2017)
6 more