› 1bbs

X-ray diffraction
2.8Å resolution

X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS

Released:
DOI: 10.2210/pdb1bbs/pdb
PDB entry 1bbs coloured by chain, front view.
PDB entry 1bbs coloured by chain, side view.
PDB entry 1bbs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C
Nature 357 466-72 (1992)
PMID: 1608447

Function and Biology Details

Reaction catalysed: 
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-133565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 37.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00797 (Residues: 67-406; Coverage: 89%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P213
Unit cell:
a: 143.1Å b: 143.1Å c: 143.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 not available not available
Expression system: Not provided

Quick links

Citations

13 review citations

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes.
Dougherty et al. (1993)
12 more

13 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
12 more