› 1bft

X-ray diffraction
2Å resolution

STRUCTURE OF NF-KB P50 HOMODIMER BOUND TO A KB SITE

Released:
DOI: 10.2210/pdb1bft/pdb
PDB entry 1bft coloured by chain, front view.
PDB entry 1bft coloured by chain, side view.
PDB entry 1bft coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits.
Huang DB, Huxford T, Chen YQ, Ghosh G
Structure 5 1427-36 (1997)
PMID: 9384558

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170005 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor p65 Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.47 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q04207 (Residues: 191-291; Coverage: 18%)
Gene names: Nfkb3, Rela
Sequence domains: Rel homology dimerisation domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 55.5Å b: 74.49Å c: 105.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 0.294

Quick links

Citations

12 review citations

Transcriptional regulation via the NF-kappaB signaling module.
Hoffmann et al. (2006)
11 more

4 mentions without citation

Interaction preferences across protein-protein interfaces of obligatory and non-obligatory components are different.
De et al. (2005)
3 more