› 1bil

X-ray diffraction
2.4Å resolution

CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

Released:
DOI: 10.2210/pdb1bil/pdb
PDB entry 1bil coloured by chain, front view.
PDB entry 1bil coloured by chain, side view.
PDB entry 1bil coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
Tong L, Pav S, Lamarre D, Simoneau B, Lavallée P, Jung G
J Biol Chem 270 29520-4 (1995)
PMID: 7493993

Function and Biology Details

Reaction catalysed: 
Cleavage of Leu-|- bond in angiotensinogen to generate angiotensin I.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133568 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Renin Chains: A, B
Molecule details ›
Chains: A, B
Length: 337 amino acids
Theoretical weight: 36.94 KDa
Source organism: Homo sapiens
Expression system: STABLY TRANSFERRED DOG EPITHELIAL CELL
UniProt:
  • Canonical: P00797 (Residues: 70-406; Coverage: 88%)
Gene name: REN
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand 0IU 2 x 0IU
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P213
Unit cell:
a: 143.1Å b: 143.1Å c: 143.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.17 not available
Expression system: STABLY TRANSFERRED DOG EPITHELIAL CELL

Quick links

Citations

2 review citations

Therapeutic peptides and peptidomimetics.
Kieber-Emmons et al. (1997)
1 more

4 mentions without citation

The Versatile Gasdermin Family: Their Function and Roles in Diseases.
Zou et al. (2021)
3 more