› 1blq

Solution NMR

STRUCTURE AND INTERACTION SITE OF THE REGULATORY DOMAIN OF TROPONIN-C WHEN COMPLEXED WITH THE 96-148 REGION OF TROPONIN-I, NMR, 29 STRUCTURES

Released:
DOI: 10.2210/pdb1blq/pdb
PDB entry 1blq coloured by chain, ensemble of 29 models, front view.
PDB entry 1blq coloured by chain, ensemble of 29 models, side view.
PDB entry 1blq coloured by chain, ensemble of 29 models, top view.
Source organism: Gallus gallus
Primary publication:
Structure and interaction site of the regulatory domain of troponin-C when complexed with the 96-148 region of troponin-I.
McKay RT, Pearlstone JR, Corson DC, Gagné SM, Smillie LB, Sykes BD
Biochemistry 37 12419-30 (1998)
PMID: 9730814

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.98 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P02588 (Residues: 2-91; Coverage: 55%)
Gene name: TNNC2
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

2 review citations

The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.
Sorsa et al. (2004)
1 more

1 mention without citation

The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat.
Schulze-Gahmen et al. (2013)