› 1bmp

X-ray diffraction
2.8Å resolution

BONE MORPHOGENETIC PROTEIN-7

Released:
DOI: 10.2210/pdb1bmp/pdb
PDB entry 1bmp coloured by chain, front view.
PDB entry 1bmp coloured by chain, side view.
PDB entry 1bmp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD
Proc Natl Acad Sci U S A 93 878-83 (1996)
PMID: 8570652

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148281 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein 7 Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18075 (Residues: 293-431; Coverage: 35%)
Gene names: BMP7, OP1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 99.46Å b: 99.46Å c: 42.09Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.227 0.308
Expression system: Cricetulus griseus

Quick links

Citations

61 review citations

TGF-beta signal transduction.
Massagué J. (1998)
60 more

9 mentions without citation

BMP Signaling Pathway in Dentin Development and Diseases.
Liu et al. (2022)
8 more