› 1bqy

X-ray diffraction
2.5Å resolution

Plasminogen activator (TSV-PA) from snake venom

Released:
DOI: 10.2210/pdb1bqy/pdb
PDB entry 1bqy coloured by chain, front view.
PDB entry 1bqy coloured by chain, side view.
PDB entry 1bqy coloured by chain, top view.
Source organism: Trimeresurus stejnegeri
Primary publication:
The crystal structure of the novel snake venom plasminogen activator TSV-PA: a prototype structure for snake venom serine proteinases.
Parry MA, Jacob U, Huber R, Wisner A, Bon C, Bode W
Structure 6 1195-206 (1998)
PMID: 9753698

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Venom plasminogen activator TSV-PA Chains: A, B
Molecule details ›
Chains: A, B
Length: 234 amino acids
Theoretical weight: 25.63 KDa
Source organism: Trimeresurus stejnegeri
Expression system: Escherichia coli
UniProt:
  • Canonical: Q91516 (Residues: 25-258; Coverage: 98%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand 0GJ 2 x 0GJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 45.29Å b: 67.42Å c: 163.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 0.258
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved.
Serrano et al. (2005)
7 more

10 mentions without citation

Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins.
Doley et al. (2009)
9 more