› 1bsx

X-ray diffraction
3.7Å resolution

STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS

Released:
DOI: 10.2210/pdb1bsx/pdb
PDB entry 1bsx coloured by chain, front view.
PDB entry 1bsx coloured by chain, side view.
PDB entry 1bsx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and specificity of nuclear receptor-coactivator interactions.
Darimont BD, Wagner RL, Apriletti JW, Stallcup MR, Kushner PJ, Baxter JD, Fletterick RJ, Yamamoto KR
Genes Dev 12 3343-56 (1998)
PMID: 9808622

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145482 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thyroid hormone receptor beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 29.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
PROTEIN (GRIP1) Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand T3 2 x T3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3121
Unit cell:
a: 95.2Å b: 95.2Å c: 137.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.249 0.299
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

127 review citations

Intrinsically unstructured proteins and their functions.
Dyson et al. (2005)
126 more

13 mentions without citation

An overview of the structures of protein-DNA complexes.
Luscombe et al. (2000)
12 more