› 1bte

X-ray diffraction
1.5Å resolution

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR

Released:
DOI: 10.2210/pdb1bte/pdb
PDB entry 1bte coloured by chain, front view.
PDB entry 1bte coloured by chain, side view.
PDB entry 1bte coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase.
Greenwald J, Fischer WH, Vale WW, Choe S
Nat Struct Biol 6 18-22 (1999)
PMID: 9886286

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150922 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activin receptor type-2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 97 amino acids
Theoretical weight: 11.51 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P27038 (Residues: 25-121; Coverage: 20%)
Gene names: Acvr2, Acvr2a
Sequence domains: Activin types I and II receptor domain
Structure domains: CD59

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3
Unit cell:
a: 71.63Å b: 71.63Å c: 37.38Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.181 0.222
Expression system: Komagataella pastoris

Quick links

Citations

26 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
25 more

5 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
4 more