› 1bw0

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF TYROSINE AMINOTRANSFERASE FROM TRYPANOSOMA CRUZI

Released:
DOI: 10.2210/pdb1bw0/pdb
PDB entry 1bw0 coloured by chain, front view.
PDB entry 1bw0 coloured by chain, side view.
PDB entry 1bw0 coloured by chain, top view.
Source organism: Trypanosoma cruzi
Primary publication:
Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode.
Blankenfeldt W, Nowicki C, Montemartini-Kalisz M, Kalisz HM, Hecht HJ
Protein Sci 8 2406-17 (1999)
PMID: 10595543

Function and Biology Details

Reaction catalysed: 
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 416 amino acids
Theoretical weight: 46.45 KDa
Source organism: Trypanosoma cruzi
UniProt:
  • Canonical: P33447 (Residues: 1-416; Coverage: 100%)
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand LLP 2 x LLP

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P21
Unit cell:
a: 61.6Å b: 102.2Å c: 77.9Å
α: 90° β: 110.3° γ: 90°
R-values:
R R work R free
0.157 0.157 0.214

Quick links

Citations

5 review citations

The manifold of vitamin B6 dependent enzymes.
Schneider et al. (2000)
4 more

5 mentions without citation

The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction.
Manning et al. (2008)
4 more