› 1by9

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS TYPE-16: IMPLICATIONS FOR ITS DNA BINDING-SITE SELECTION MECHANISM

Released:
DOI: 10.2210/pdb1by9/pdb
PDB entry 1by9 coloured by chain, front view.
PDB entry 1by9 coloured by chain, side view.
PDB entry 1by9 coloured by chain, top view.
Source organism: Human papillomavirus type 16
Primary publication:
Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: implications for its DNA binding-site selection mechanism.
Hegde RS, Androphy EJ
J Mol Biol 284 1479-89 (1998)
PMID: 9878365

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136580 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulatory protein E2 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.37 KDa
Source organism: Human papillomavirus type 16
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03120 (Residues: 285-365; Coverage: 22%)
Gene name: E2
Sequence domains: E2 (early) protein, C terminal
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P3121
Unit cell:
a: 43.775Å b: 43.775Å c: 76.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.195 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The papillomavirus E2 proteins.
McBride AA. (2013)
4 more

21 mentions without citation

Evolutionary and biophysical relationships among the papillomavirus E2 proteins.
Blakaj et al. (2009)
20 more