› 1c0q

X-ray diffraction
1Å resolution

COMPLEX OF VANCOMYCIN WITH 2-ACETOXY-D-PROPANOIC ACID

Released:
DOI: 10.2210/pdb1c0q/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1c0q coloured by chain, front view.
PDB entry 1c0q coloured by chain, side view.
PDB entry 1c0q coloured by chain, top view.
Source organism: Amycolatopsis orientalis
Primary publication:
Vancomycin binding to low-affinity ligands: delineating a minimum set of interactions necessary for high-affinity binding.
Loll PJ, Kaplan J, Selinsky BS, Axelsen PH
J Med Chem 42 4714-9 (1999)
PMID: 10579833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
VANCOMYCIN Chains: A, B
Molecule details ›
Chains: A, B
Length: 7 amino acids
Theoretical weight: 1.15 KDa
Source organism: Amycolatopsis orientalis
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, RER
Carbohydrate polymer
2 bound ligands:
Ligand CL 3 x CL
Ligand LAC 1 x LAC
2 modified residues:
Ligand GHP 4 x GHP
Ligand OMY 2 x OMY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X12B
Spacegroup: P43212
Unit cell:
a: 28.4Å b: 28.4Å c: 65.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.119 0.119 0.139
Expression system: Not provided

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Citations

2 review citations

Mechanism of action of oritavancin and related glycopeptide antibiotics.
Allen et al. (2003)
1 more