› 1c0y

Solution NMR

SOLUTION STRUCTURE OF THE [AF]-C8-DG ADDUCT POSITIONED OPPOSITE DA AT A TEMPLATE-PRIMER JUNCTION

Released:
DOI: 10.2210/pdb1c0y/pdb
PDB entry 1c0y coloured by chain, ensemble of 6 models, front view.
PDB entry 1c0y coloured by chain, ensemble of 6 models, side view.
PDB entry 1c0y coloured by chain, ensemble of 6 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structures of aminofluorene [AF]-stacked conformers of the syn [AF]-C8-dG adduct positioned opposite dC or dA at a template-primer junction.
Gu Z, Gorin A, Hingerty BE, Broyde S, Patel DJ
Biochemistry 38 10855-70 (1999)
PMID: 10451382

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113521 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 13 nucleotides
Theoretical weight: 3.88 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*GP*AP*TP*GP*GP*TP*AP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.13 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand AF 1 x AF
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: RELAXATION MATRIX REFINEMENT
Expression system: Not provided

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Citations

3 review citations

Factors that influence the mutagenic patterns of DNA adducts from chemical carcinogens.
Seo et al. (2000)
2 more

1 mention without citation

Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor.
Jain et al. (2013)