› 1c6x

X-ray diffraction
2.5Å resolution

ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.

Released:
DOI: 10.2210/pdb1c6x/pdb
PDB entry 1c6x coloured by chain, front view.
PDB entry 1c6x coloured by chain, side view.
PDB entry 1c6x coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
Munshi S, Chen Z, Yan Y, Li Y, Olsen DB, Schock HB, Galvin BB, Dorsey B, Kuo LC
Acta Crystallogr D Biol Crystallogr 56 381-8 (2000)
PMID: 10739910

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.8 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: O09893 (Residues: 1-99; Coverage: 100%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand 3IN 1 x 3IN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 88.21Å b: 88.21Å c: 32.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.3
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Current perspectives on HIV-1 antiretroviral drug resistance.
Iyidogan et al. (2014)
16 other articles

2 mentions without citation

Protein subunit interfaces: heterodimers versus homodimers.
Zhanhua et al. (2005)
1 more