› 1c7z

X-ray diffraction
2.6Å resolution

REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE

Released:
DOI: 10.2210/pdb1c7z/pdb
PDB entry 1c7z coloured by chain, front view.
PDB entry 1c7z coloured by chain, side view.
PDB entry 1c7z coloured by chain, top view.
Source organism: Rattus norvegicus
Entry authors: Lee YH, Olson TW, McClard RW, Witte JF, McFarlan SC, Banaszak LJ, Levitt DG, Lange AJ

Function and Biology Details

Reactions catalysed: 
ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate
Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139858 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 191 amino acids
Theoretical weight: 22.18 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P07953 (Residues: 252-441; Coverage: 40%)
Gene name: Pfkfb1
Sequence domains: Histidine phosphatase superfamily (branch 1)
Structure domains: Phosphoglycerate mutase-like

Ligands and Environments

2 bound ligands:
Ligand PO4 2 x PO4
Ligand G3H 2 x G3H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 47.7Å b: 55.3Å c: 90.6Å
α: 90° β: 93.6° γ: 90°
R-values:
R R work R free
0.194 0.194 0.253
Expression system: Escherichia coli

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