› 1c8p

Solution NMR

NMR STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE COMMON BETA-CHAIN IN THE GM-CSF, IL-3 AND IL-5 RECEPTORS

Released:
DOI: 10.2210/pdb1c8p/pdb
PDB entry 1c8p coloured by chain, ensemble of 20 models, front view.
PDB entry 1c8p coloured by chain, ensemble of 20 models, side view.
PDB entry 1c8p coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5.
Mulhern TD, Lopez AF, D'Andrea RJ, Gaunt C, Vandeleur L, Vadas MA, Booker GW, Bagley CJ
J Mol Biol 297 989-1001 (2000)
PMID: 10736232

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytokine receptor common subunit beta Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 12.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32927 (Residues: 338-438; Coverage: 12%)
Gene names: CSF2RB, IL3RB, IL5RB
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

3 review citations

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease.
Hercus et al. (2009)
2 more

2 mentions without citation

Identifying unexpected therapeutic targets via chemical-protein interactome.
Yang et al. (2010)
1 more