› 1c8z

X-ray diffraction
1.9Å resolution

C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN

Released:
DOI: 10.2210/pdb1c8z/pdb
PDB entry 1c8z coloured by chain, front view.
PDB entry 1c8z coloured by chain, side view.
PDB entry 1c8z coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Implication of tubby proteins as transcription factors by structure-based functional analysis.
Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L
Science 286 2119-25 (1999)
PMID: 10591637

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tubby protein Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 30 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P50586 (Residues: 241-505; Coverage: 53%)
Gene names: Rd5, Tub
Sequence domains: Tub family
Structure domains: Tubby Protein; Chain A

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 43.536Å b: 51.023Å c: 121.074Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.265
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Leber congenital amaurosis: genes, proteins and disease mechanisms.
den Hollander et al. (2008)
23 more

2 mentions without citation

The role of hydrophobic interactions in positioning of peripheral proteins in membranes.
Lomize et al. (2007)
1 more