› 1c9l

X-ray diffraction
2.9Å resolution

PEPTIDE-IN-GROOVE INTERACTIONS LINK TARGET PROTEINS TO THE B-PROPELLER OF CLATHRIN

Released:
DOI: 10.2210/pdb1c9l/pdb
PDB entry 1c9l coloured by chain, front view.
PDB entry 1c9l coloured by chain, side view.
PDB entry 1c9l coloured by chain, top view.
Source organisms:
Primary publication:
Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin.
ter Haar E, Harrison SC, Kirchhausen T
Proc Natl Acad Sci U S A 97 1096-100 (2000)
PMID: 10655490

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145835 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Clathrin heavy chain 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 357 amino acids
Theoretical weight: 39.75 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11442 (Residues: 3-359; Coverage: 21%)
Gene name: Cltc
Sequence domains:
Structure domains: Clathrin heavy-chain terminal domain
B-ADAPTIN 3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 8 amino acids
Theoretical weight: 980 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: C2
Unit cell:
a: 137.62Å b: 130.787Å c: 78.468Å
α: 90° β: 115.47° γ: 90°
R-values:
R R work R free
0.221 0.221 0.263
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

43 review citations

Regulation of receptor trafficking by GRKs and arrestins.
Moore et al. (2007)
42 more

5 mentions without citation

Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.
Pirruccello et al. (2012)
4 more