› 1c9q

Solution NMR

AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-2 DOMAIN OF XIAP

Released:
DOI: 10.2210/pdb1c9q/pdb
PDB entry 1c9q coloured by chain, front view.
PDB entry 1c9q coloured by chain, side view.
PDB entry 1c9q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW
Nature 401 818-22 (1999)
PMID: 10548111

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase XIAP Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P98170 (Residues: 124-240; Coverage: 24%)
Gene names: API3, BIRC4, IAP3, XIAP
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS, SIMULATED ANNEALING
Expression system: Escherichia coli

Quick links

Citations

78 review citations

IAP proteins: blocking the road to death's door.
Salvesen et al. (2002)
77 more

8 mentions without citation

In silico structure-based approaches to discover protein-protein interaction-targeting drugs.
Shin et al. (2017)
7 more