› 1ccq

Solution NMR

NMR STRUCTURE WITH TIGHTLY BOUND WATER MOLECULES OF CYTOTOXIN II (CARDIOTOXIN) FROM NAJA NAJA OXIANA IN AQUEOUS SOLUTION (MINOR FORM).

Released:
DOI: 10.2210/pdb1ccq/pdb
PDB entry 1ccq coloured by chain, ensemble of 20 models, front view.
PDB entry 1ccq coloured by chain, ensemble of 20 models, side view.
PDB entry 1ccq coloured by chain, ensemble of 20 models, top view.
Source organism: Naja oxiana
Primary publication:
Two forms of cytotoxin II (cardiotoxin) from Naja naja oxiana in aqueous solution: spatial structures with tightly bound water molecules.
Dementieva DV, Bocharov EV, Arseniev AS
Eur J Biochem 263 152-62 (1999)
PMID: 10429199

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxin 2 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.65 KDa
Source organism: Naja oxiana
UniProt:
  • Canonical: P01441 (Residues: 1-60; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING BY MOLECULAR DYNAMICS IN TORSION ANGLE SPACE

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Citations

2 review citations

The role of hydrophobic /hydrophilic balance in the activity of structurally flexible vs. rigid cytolytic polypeptides and analogs developed on their basis.
Dubovskii et al. (2018)
1 more

3 mentions without citation

Cobra cytotoxins: structural organization and antibacterial activity.
Dubovskii et al. (2014)
2 more