› 1ce2

X-ray diffraction
2.5Å resolution

STRUCTURE OF DIFERRIC BUFFALO LACTOFERRIN AT 2.5A RESOLUTION

Released:
DOI: 10.2210/pdb1ce2/pdb
PDB entry 1ce2 coloured by chain, front view.
PDB entry 1ce2 coloured by chain, side view.
PDB entry 1ce2 coloured by chain, top view.
Source organism: Bubalus bubalis
Primary publication:
Structure of buffalo lactoferrin at 2.5 A resolution using crystals grown at 303 K shows different orientations of the N and C lobes.
Karthikeyan S, Paramasivam M, Yadav S, Srinivasan A, Singh TP
Acta Crystallogr D Biol Crystallogr 55 1805-13 (1999)
PMID: 10531476

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactotransferrin Chain: A
Molecule details ›
Chain: A
Length: 689 amino acids
Theoretical weight: 75.85 KDa
Source organism: Bubalus bubalis
UniProt:
  • Canonical: O77698 (Residues: 20-708; Coverage: 100%)
Gene name: LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand FE 2 x FE
Ligand CO3 2 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 77.462Å b: 91.035Å c: 131.507Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.265

Quick links

Citations

5 review citations

Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis.
Rosa et al. (2017)
4 more