› 1ckw

Solution NMR

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION

Released:
DOI: 10.2210/pdb1ckw/pdb
PDB entry 1ckw coloured by chain, ensemble of 13 models, front view.
PDB entry 1ckw coloured by chain, ensemble of 13 models, side view.
PDB entry 1ckw coloured by chain, ensemble of 13 models, top view.
Source organism: Ovis aries
Primary publication:
Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation.
Massiah MA, Ko YH, Pedersen PL, Mildvan AS
Biochemistry 38 7453-61 (1999)
PMID: 10360942

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169447 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystic fibrosis transmembrane conductance regulator Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.91 KDa
Source organism: Ovis aries
Expression system: Not provided
UniProt:
  • Canonical: Q00555 (Residues: 497-522; Coverage: 2%)
Gene names: ABCC7, CFTR

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Not provided

Quick links

Citations

6 review citations

Disease-related misassembly of membrane proteins.
Sanders et al. (2004)
5 more

1 mention without citation

Calicivirus RNA-Dependent RNA Polymerases: Evolution, Structure, Protein Dynamics, and Function.
Smertina et al. (2019)