› 1cly

X-ray diffraction
2.5Å resolution

IGG FAB (HUMAN IGG1, KAPPA) CHIMERIC FRAGMENT (CBR96) COMPLEXED WITH LEWIS Y NONOATE METHYL ESTER

Released:
DOI: 10.2210/pdb1cly/pdb
PDB entry 1cly coloured by chain, front view.
PDB entry 1cly coloured by chain, side view.
PDB entry 1cly coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The x-ray structure of an anti-tumour antibody in complex with antigen.
Jeffrey PD, Bajorath J, Chang CY, Yelton D, Hellström I, Hellström KE, Sheriff S
Nat Struct Biol 2 466-71 (1995)
PMID: 7664109

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208540 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
IGG FAB (HUMAN IGG1, KAPPA) Chain: H
Molecule details ›
Chain: H
Length: 219 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NON 1 x NON
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P43212
Unit cell:
a: 81.7Å b: 81.7Å c: 166.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.238 0.298
Expression system: Not provided

Quick links

Citations

10 review citations

Structure and conformation of complex carbohydrates of glycoproteins, glycolipids, and bacterial polysaccharides.
Bush et al. (1999)
9 more

9 mentions without citation

Strategies and Tactics for the Development of Selective Glycan-Binding Proteins.
Ward et al. (2021)
8 more